From the category archives:

MRSA in the Military

The composer’s untimely death at the age of 35 has remained a mystery ever since he passed away in the early hours of 5 December 1791.  Now a group of Dutch researchers has suggested that he died from a bacterial infection spread by soldiers which was rife in Vienna at the time.

By studying the city’s death register, they found that the three most common causes of death among men of his age were tuberculosis, severe weight loss and a condition called ‘oedema’ or ‘dropsy’ – an accumulation of fluids causing the body to swell up.  Mozart’s symptoms match the last of the three, according to Dr Richard Zeger, from the Academic Medical Centre in Amsterdam, who said it could have been caused by a bacterial infection.

He said: “I think you can compare this to a superbug like MRSA or C.difficile.”  Eyewitnesses who saw Mozart days before he died, including his sister-in-law Sophie Haibel, said he was covered in a rash – consistent with a bacterial infection – and severely swollen – consistent with oedema or dropsy.

via Mozart ‘was killed by superbug like MRSA’ – Telegraph.

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Of the 3447 soldiers screened, 134 3.9% had MRSA colonization. Of the 3066 89% who completed the study, 39 developed culture-confirmed MRSA abscesses. USA300 represented 53% of colonizing isolates, but was responsible for 97% of the abscesses P<0.001. When compared with colonizing isolates, USA300, PVL, ACME, and type IV SCCmec were significantly associated with MRSA abscess isolates. After multivariate analysis, risk factors for MRSA colonization were a history of SSTI and a history of hospitalization. Although various MRSA strains may colonize soldiers, USA300 is the most virulent when evaluated prospectively; and PVL, ACME, and type IV SCCmec are associated with these abscesses.

via Molecular Epidemiology and Presence of Virulence Factors in Methicillin-Resistant Staphylococcus aureus Colonizing and Infecting Soldiers — Ellis et al., 10.1128/JCM.02352-08 — Journal of Clinical Microbiology.

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