Link: PharmaLive: New Drug Technology Being Developed by Wisconsin Start-Up Featured in Nature.
The study led by Centrose co-founder and UW-Madison Professor Jon Thorson was published last week in the Journal of the American Chemical Society. Nature reports that Centrose’s technology allows for " … an easier way to create vancomycin-like compounds that demonstrate more potency than their predecessor. The study highlights the simplicity of generating large libraries of such analogs [compounds modified using Centrose's unique technology] for optimizing antibiotics to target highly resistant pathogens."
Centrose also plans to use its unique technology for methicillin-resistant Staphylococcus aureus, or MRSA, a bacterium responsible for more than 60% of hospital staph infections that can no longer be treated with methicillin, a penicillin-class antibiotic. A new national study released Monday by the Association for Professionals in Infection and Epidemiology (APIC) found that 46 out of every 1,000 hospital patients were either infected or colonized with MRSA. This rate is eight to 11 times greater than previous MRSA estimates
